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Churning: The association between health care transitions and feeding tube insertion for nursing home residents with advanced cognitive impairment

Instead, they work through several pathways at once, including: Slowing how quickly the stomach empties (which keeps you fuller longer) Reducing appetite signals in the brain Supporting insulin release Blunting glucagon (a hormone that raises blood sugar) Tirzepatide goes a step further by acting on a second hormone pathway (GIP) in addition to GLP-1, which may further support metabolic regulation

Second, and just as important, the benefit reversed when the drug was stopped visceral fat re-accumulated after discontinuation